The Antihyperglycemic Activity of Bruguiera gymnorrhiza Roots Extract in STZ-induced Diabetic Mice
Keywords:
Mangrove, diabetes, Bruguiera gymnorrhizaAbstract
Mangrove plants are believed to possess a wide range of bioactive compounds due to their ability to thrive in harsh conditions enduring high salinity, low air humidity and high temperature. Bruguiera gymnorrhiza is one of the mangrove species that is commonly found in Sabah and its root has been discovered to have antidiabetic activity. However, previous investigations focused solely on ethanolic extract of Bruguiera gymnorrhiza root (BGR). Thus, this study aimed to assess antihyperglycemic activity of BGR methanolic extract in various fractions (aqueous, butanol, chloroform) using streptozocin-induced diabetic mice as an experimental model. The diabetic mice were administered different fractions of BGR extract at dose of 250 mg/kg with metformin (200 mg/kg) serves as standard drug. Blood glucose levels were measured on day 0th, 7th and 14th following the oral administration of BGR fractions in a fasting state mice. After 14 days treatment period, the results showed that the aqueous fraction of BGR extract significantly reduced the blood glucose levels in diabetic mice compared to other BGR fractions. The significant antihyperglycemic effect observed in aqueous fraction of BGR extract strongly indicates the presence of major potent antidiabetic components for decreasing the elevated blood glucose levels in diabetic mice.
References
Bader, G. N., Mir, P. A., & Ali, S. (2017). Evaluation of Anti Inflammatory and Analgesic Activity of Rhizome of Swertia Petiolata. Am. J. Pharm. Tech. Res, 7, 332-343.
Bowker, S. L., Majumdar, S. R., Veugelers, P., & Johnson, J. A. (2006). Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin. Diabetes Care, 29(2). https://doi.org/10.2337/diacare.29.02.06.dc05-1558
Chandramohan, G., Ignacimuthu, S., & Pugalendi, K. V. (2008). A novel compound from Casearia esculenta (Roxb.) root and its effect on carbohydrate metabolism in streptozotocin-diabetic rats. European Journal of Pharmacology, 590(1–3). https://doi.org/10.1016/j.ejphar.2008.02.082
Clarkson, C., Maharaj, V. J., Crouch, N. R., Grace, O. M., Pillay, P., Matsabisa, M. G., Bhagwandin, N., Smith, P. J., & Folb, P. I. (2004). In vitro antiplasmodial activity of medicinal plants native to or naturalised in South Africa. Journal of Ethnopharmacology, 92(2–3). https://doi.org/10.1016/j.jep.2004.02.011
Egan, A. M., & Dinneen, S. F. (2019). What is diabetes? In Medicine (United Kingdom) (Vol. 47, Issue 1). https://doi.org/10.1016/j.mpmed.2018.10.002
Food and Agriculture Organization. (2020). Global Forest Resources Assessment 2020: Main report. In Reforming China’s Healthcare System.
International Diabetes Federation. (2021). IDF Diabetes Atlas Tenth edition 2021. International Diabetes Federation.
IPH, I. for P. H., NIH, N. I. of H., & Malaysia, M. of H. (2019). National Health and Morbidity Survey (NHMS) 2019: NCDs - Non-Communicable Diseases: Risk Factors and other Health Problems. In Institute for Public Health, National Institutes of Health (NIH), Ministry of Health Malaysia (Vol. 1).
Ivemeyer, S., Smolders, G., Brinkmann, J., Gratzer, E., Hansen, B., Henriksen, B. I. F., Huber, J., Leeb, C., March, S., Mejdell, C., Nicholas, P., Roderick, S., Stöger, E., Vaarst, M., Whistance, L. K., Winckler, C., & Walkenhorst, M. (2012). Impact of animal health and welfare planning on medicine use, herd health and production in European organic dairy farms. Livestock Science, 145(1–3). https://doi.org/10.1016/j.livsci.2011.12.023
Kathiresan, K., & Bingham, B. L. (2001). Biology of mangroves and mangrove ecosystems. In Advances in Marine Biology (Vol. 40). https://doi.org/10.1016/S0065-2881(01)40003-4
Kauffman, J. B., Heider, C., Cole, T. G., Dwire, K. A., & Donato, D. C. (2011). Ecosystem carbon stocks of micronesian mangrove forests. Wetlands, 31(2). https://doi.org/10.1007/s13157-011-0148-9
Lagarto Parra, A., Silva Yhebra, R., Guerra Sardiñas, I., & Iglesias Buela, L. (2001). Comparative study of the assay of Artemia salina L. And the estimate of the medium lethal dose (LD50 value) in mice, to determine oral acute toxicity of plant extracts. Phytomedicine, 8(5). https://doi.org/10.1078/0944-7113-00044
Meyer, B. N., Ferrigni, N. R., Putnam, J. E., Jacobsen, L. B., Nichols, D. E., & McLaughlin, J. L. (1982). Brine shrimp: A convenient general bioassay for active plant constituents. Planta Medica, 45(1). https://doi.org/10.1055/s-2007-971236
Monami, M., Lamanna, C., Balzi, D., Marchionni, N., & Mannucci, E. (2009). Sulphonylureas and cancer: A case-control study. Acta Diabetologica, 46(4). https://doi.org/10.1007/s00592-008-0083-2
Olaniyi, A. O., Abdullah, A. M., Ramli, M. F., & Alias, M. S. (2012). Assessment of drivers of coastal land use change in Malaysia. Ocean and Coastal Management, 67. https://doi.org/10.1016/j.ocecoaman.2012.05.029
Sachithanandam, V., Lalitha, P., Parthiban, A., Mageswaran, T., Manmadhan, K., & Sridhar, R. (2019). A Review on Antidiabetic Properties of Indian Mangrove Plants with Reference to Island Ecosystem. In Evidence-based Complementary and Alternative Medicine (Vol. 2019). https://doi.org/10.1155/2019/4305148
Saravana, G., & Pari, L. (2006). Effects of Syzygium cumini bark on blood glucose, plasme insulin and C-peptide in streptozotocin-induced diabetic rats. International Journal of Endocrinology Metabolism, 4.
Sathasivampillai, S. V., Rajamanoharan, P. R. S., Munday, M., & Heinrich, M. (2017). Plants used to treat diabetes in Sri Lankan Siddha Medicine – An ethnopharmacological review of historical and modern sources. In Journal of Ethnopharmacology (Vol. 198). https://doi.org/10.1016/j.jep.2016.07.053
Singh, N., Vikram Patel, A., Alok, S., Kannojia, P., Garud, N., & Mehta, S. C. (2010). ANTI-DIABETIC ACTIVITY OF BRUGUIERA GYMNORHIZA ROOT. IJPSR, 1(5). www.ijpsr.com
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