Apoptosis: Dual Role in Aetiology and Cure

Authors

  • Aye Aye Wynn
  • Ohnmar Myint
  • Nang Khin Mya

Keywords:

apoptosis, infections, non-communicable diseases

Abstract

Apoptosis is a programmed cell death which occurs following a variety of stimuli. Physiologically the process is important for morphogenesis of organs and homeostasis of different types of cells. Apoptotic cell death is responsible for a variety of pathologic states such as elimination of cell death in mutated cells, infected cells, tumour cells and transplant rejection well as the pathological atrophy. In this review, there is discussion about the control of apoptosis, detection methods of apoptosis, its association with infectious and non-communicable diseases. Intracellular microorganisms survive through inhibition of host cell apoptosis as well as they destroy the parenchymal cells causing impaired functions. It plays important role in tumourigenesis. There are possible therapeutic roles of drugs that modify apoptosis in human diseases.

Author Biographies

Aye Aye Wynn

Department of Pathobiology and Medical Diagnostics,
Faculty of Medicine and Health Sciences,
Universiti Malaysia Sabah,
Kota Kinabalu, Sabah, Malaysia

Ohnmar Myint

Department of Pathobiology and Medical Diagnostics,
Faculty of Medicine and Health Sciences,
Universiti Malaysia Sabah,
Kota Kinabalu, Sabah, Malaysia

Nang Khin Mya

Department of Pathobiology and Medical Diagnostics,
Faculty of Medicine and Health Sciences,
Universiti Malaysia Sabah,
Kota Kinabalu, Sabah, Malaysia

Published

2019-09-28

How to Cite

Wynn, A. A., Myint, O., & Mya, N. K. (2019). Apoptosis: Dual Role in Aetiology and Cure. Borneo Journal of Medical Sciences (BJMS), 5. Retrieved from https://jurcon.ums.edu.my/ojums/index.php/bjms/article/view/1498