Telomere and a Final Verdict for Cellular Senescence

Aye Aye  Wynn; Nang Khin  Mya

doi:10.51200/bjms.v14i3.2265

Telomere and a Final Verdict for Cellular Senescence

Authors

Aye Aye Wynn Department of Pathology and Medical Diagnostics, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia
Nang Khin Mya Department of Pathology and Medical Diagnostics, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, Sabah, Malaysia

DOI:

https://doi.org/10.51200/bjms.v14i3.2265

Keywords:

Telomere, cellular senescence, eukaryotic cells, tumourigenesis

Abstract

Telomeres are specialized DNA complexes found at the end of all chromosomes. Human, as a member of eukaryotic cells, requires telomeres to maintain the length and the stability of chromosomes. Telomeres lose their non-coding DNA sequence to protect the genetic information on the chromosomes. Shortening of telomeres occurs in most somatic cells after sufficient cell division in a human lifetime. Normal haemopoietic cells or stem cells possess telomerase enzyme to restore telomeres and allow further replication. Telomere dysfunction is the origin of several degenerative disorders and also predispose to cancer. Roles of telomere in carcinogenesis and ageing related disorders are reviewed.

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9_BJMS_Vol.14 (3) SEPT 2020

Published

2020-09-30

How to Cite

Wynn, A. A. ., & Mya, N. K. . (2020). Telomere and a Final Verdict for Cellular Senescence. Borneo Journal of Medical Sciences (BJMS), 14(3), 57. https://doi.org/10.51200/bjms.v14i3.2265

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Issue

Vol. 14 No. 3 (2020): BORNEO JOURNAL OF MEDICAL SCIENCES VOLUME 14, ISSUE 3, SEPTEMBER 2020

Section

Short communication

License

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