A Rare Life threatening Side Effect of Trimethoprim-Sulfamethoxazole: A Case Report

Benjamin Ng Han Sim; Low Qin Jian

doi:10.51200/bjms.v11i2.582

A Rare Life threatening Side Effect of Trimethoprim-Sulfamethoxazole: A Case Report

Authors

Benjamin Ng Han Sim Department of Medicine Segamat Hospital, Johor,Malaysia
Low Qin Jian Medical Department, Melaka General Hospital Melaka

DOI:

https://doi.org/10.51200/bjms.v11i2.582

Keywords:

Trimethoprim-Sulfamethoxazole, hyperkalemia, meliodosis

Abstract

Trimethoprim-Sulfamethoxazole is associated with rare life threatening side effect of hyperkalemia. We described a case of life threatening hyperkalemia in a patient treated with Trimethoprim-Sulfamethoxazole as part of the eradication therapy for Meliodosis.

Author Biographies

Benjamin Ng Han Sim, Department of Medicine Segamat Hospital, Johor,Malaysia

Dr.Benjamin Ng Han Sim

MD(hons)(UMS),

MRCP(UK), MRCP(London),

SCE(Acute Medicine,UK)

General Physician,

Department of Medicine,

Segamat Hospital,

Johor Malaysia

Area of Interest: Acute Medicine, Neurology

Low Qin Jian, Medical Department, Melaka General Hospital Melaka

Medical Officer, Medical Department, Melaka General Hospital MD(UMS), MRCP(UK)

References

Antoniou T, et al. Trimethoprim-sulfamethoxazole-induced hyperkalemia in patients receiving inhibitors of the renin-angiotensin system: a population-based study, Arch Intern Med. 2010 Jun 28;170(12);1045-9.doi:10.1001/archinternmed.2010.142

PerazellaMA,et al. Trimethoprim-sulfamethoxazole: hyperkalemia is an important complication regardless of dose, Clin Nephrol.1996 Sep;46(3):187-92.

AlappanR,et al. Hyperkalemia in hospitalized patients treated with trimethoprim-sulfamethoxazole. Ann Intern Med.1996 Feb 1;124(3):316-20.

Velazquez H,et al. Renal mechanism of trimethoprim-induced hyperkalemia, Ann Intern Med. 1993 Aug 15; 119(4):296-301.

ChetchotisakdP,et al. Trimethoprim-sulfamethoxazole versus trimethoprim-sulfamethoxazole plus doxycycline as oral eradicative treatment for meliodosis (MERTH); a multicenter, double-blind, non-inferiority, randomized controlled trial, Lancet.2014 Mar; 383(9919):807-14. Epub2013 Nov25.

RajchanuvongA,et al. A prospective comparison of co-amoxiclav and the combination of chromphenicol, doxycycline, and co-trimoxazole for the oral maintenance treatment of meliodosis, Trans R Soc Trop Med Hyg. 1995; 89(5):546.

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Published

2017-07-19

How to Cite

Ng Han Sim, B., & Jian, L. Q. (2017). A Rare Life threatening Side Effect of Trimethoprim-Sulfamethoxazole: A Case Report. Borneo Journal of Medical Sciences (BJMS), 11(2), 35. https://doi.org/10.51200/bjms.v11i2.582

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Issue

Vol. 11 No. 2 (2017): BORNEO JOURNAL OF MEDICAL SCIENCES VOLUME 11, ISSUE 2, 2017

Section

Case report

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